研究成果

  • 中心主任記兼產學合作組組長 沈湯龍
    1. Chou, S.M., Lai, W.J., Hong, T.W., Lai, J.Y., Tsai, S.H., Chen, Y.H., Yu, S.H., Kao, C.H., Chu, R., Ding, S.T., Li, T.K., and Shen, T.L. (2014). Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells. Phytomedicine : international journal of phytotherapy and phytopharmacology 21, 1516-1524.
    2. Hsieh, M.Y., Fan, J.R., Chang, H.W., Chen, H.C., Shen, T.L., Teng, S.C., Yeh, Y.H., and Li, T.K. (2014). DNA topoisomerase III alpha regulates p53-mediated tumor suppression. Clinical cancer research : an official journal of the American Association for Cancer Research 20, 1489-1501.
    3. Lin, C.E., Chen, S.U., Lin, C.C., Chang, C.H., Lin, Y.C., Tai, Y.L., Shen, T.L., and Lee, H. (2012). Lysophosphatidic acid enhances vascular endothelial growth factor-C expression in human prostate cancer PC-3 cells. PloS one 7, e41096.
    4. Yang, C.Y., Huang, L.Y., Shen, T.L., and Yeh, J.A. (2010). Cell adhesion, morphology and biochemistry on nano-topographic oxidized silicon surfaces. European cells & materials 20, 415-430.
    5. Yang, C.Y., Liao, T.C., Shuai, H.H., Shen, T.L., Yeh, J.A., and Cheng, C.M. (2012). Micropatterning of mammalian cells on inorganic-based nanosponges. Biomaterials 33, 4988-4997.
  • 研究發展組組長 李財坤
    1. Chou, S.M., Huang, T.H., Chen, H.C., and Li, T.K. (2011). Calcium-induced cleavage of DNA topoisomerase I involves the cytoplasmic-nuclear shuttling of calpain 2. Cellular and molecular life sciences : CMLS 68, 2769-2784.
    2. Lee, C.H., Hsieh, M.Y., Hsin, L.W., Chen, H.C., Lo, S.C., Fan, J.R., Chen, W.R., Chen, H.W., Chan, N.L., and Li, T.K. (2012). Anthracenedione-methionine conjugates are novel topoisomerase II-targeting anticancer agents with favorable drug resistance profiles. Biochemical pharmacology 83, 1208-1216.
    3. Toh, Y.M., and Li, T.K. (2011). Mitoxantrone inhibits HIF-1alpha expression in a topoisomerase II-independent pathway. Clinical cancer research : an official journal of the American Association for Cancer Research 17, 5026-5037.
    4. Wu, C.C., Li, Y.C., Wang, Y.R., Li, T.K., and Chan, N.L. (2013). On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic acids research 41, 10630-10640.
    5. Wu, C.C., Li, T.K., Farh, L., Lin, L.Y., Lin, T.S., Yu, Y.J., Yen, T.J., Chiang, C.W., and Chan, N.L. (2011). Structural basis of type II topoisomerase inhibition by the anticancer drug etoposide. Science 333, 459-462.
    6. Yang, Y.C., Chou, H.Y., Shen, T.L., Chang, W.J., Tai, P.H., and Li, T.K. (2013). Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis. Antioxidants & redox signaling 18, 1129-1140.
    7. Yeh, Y.H., Yang, Y.C., Hsieh, M.Y., Yeh, Y.C., and Li, T.K. (2013). A negative feedback of the HIF-1alpha pathway via interferon-stimulated gene 15 and ISGylation. Clinical cancer research : an official journal of the American Association for Cancer Research 19,5927-5939.
  • 技術服務組組長 李士傑
    1. Chiang, C.L., Chen, S.S., Lee, S.J., Tsao, K.C., Chu, P.L., Wen, C.H., Hwang, S.M., Yao, C.L., and Lee, H. (2011). Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3. Stem cells 29, 1763-1773.
    2. Lai, S.L., Yao, W.L., Tsao, K.C., Houben, A.J., Albers, H.M., Ovaa, H., Moolenaar, W.H., and Lee, S.J. (2012). Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish. Development 139, 4439-4448.
    3. Lee, S.J. (2014). Dynamic regulation of the microtubule and actin cytoskeleton in zebrafish epiboly. Biochemical and biophysical research communications 452, 1-7.
    4. Shih, D.F., Hsiao, C.D., Min, M.Y., Lai, W.S., Yang, C.W., Lee, W.T., and Lee, S.J. (2013). Aromatic L-amino acid decarboxylase (AADC) is crucial for brain development and motor functions. PloS one 8, e71741.
    5. Yeh, C.M., Liu, Y.C., Chang, C.J., Lai, S.L., Hsiao, C.D., and Lee, S.J. (2011). Ptenb mediates gastrulation cell movements via Cdc42/AKT1 in zebrafish. PloS one 6, e18702.
  • 資訊智財組組長 蔡孟勳
    1. Chen, A.L., Liu, C.Y., Chen, C.H., Wang, J.F., Liao, Y.C., Chang, C.H., Tsai, M.H., Hwu, K.K., and Chen, K.Y. (2014). Reassessment of QTLs for late blight resistance in the tomato accession L3708 using a restriction site associated DNA (RAD) linkage map and highly aggressive isolates of Phytophthora infestans. PloS one 9, e96417.
    2. Yang, Y.C., Wang, D.Y., Cheng, H.F., Chuang, E.Y., and Tsai, M.H. (2015). A reliable multiplex genotyping assay for HCV using a suspension bead array. Microbial biotechnology 8, 93-102.
  • 研究員 李心予
    1. Chang, C.H., Huang, Y.L., Shyu, M.K., Chen, S.U., Lin, C.H., Ju, T.K., Lu, J., and Lee, H. (2013). Sphingosine-1-phosphate induces VEGF-C expression through a MMP-2/FGF-1/FGFR-1-dependent pathway in endothelial cells in vitro. Acta pharmacologica Sinica 34, 360-366.
    2. Ho, Y.H., Yao, C.L., Lin, K.H., Hou, F.H., Chen, W.M., Chiang, C.L., Lin, Y.N., Li, M.W., Lin, S.H., Yang, Y.J., Lin, C.C., Lu, J., Tigyi, G., and Lee, H. (2015). Opposing regulation of megakaryopoiesis by LPA receptors 2 and 3 in K562 human erythroleukemia cells. Biochimica et biophysica acta 1851, 172-183.
    3. Huang, Y.L., Chang, C.L., Tang, C.H., Lin, Y.C., Ju, T.K., Huang, W.P., and Lee, H. (2014). Extrinsic sphingosine 1-phosphate activates S1P5 and induces autophagy through generating endoplasmic reticulum stress in human prostate cancer PC-3 cells. Cellular signalling 26, 611-618.
    4. Lee, H., Chang, K.W., Yang, H.Y., Lin, P.W., Chen, S.U., and Huang, Y.L. (2013). MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells. Biochemical and biophysical research communications 437, 232-238.
    5. Lin, C.C., Lin, C.E., Lin, Y.C., Ju, T.K., Huang, Y.L., Lee, M.S., Chen, J.H., and Lee, H. (2013). Lysophosphatidic acid induces reactive oxygen species generation by activating protein kinase C in PC-3 human prostate cancer cells. Biochemical and biophysical research communications 440, 564-569.
    6. Lu, Y.C., Chen, C.N., Chu, C.Y., Lu, J., Wang, B.J., Chen, C.H., Huang, M.C., Lin, T.H., Pan, C.C., Chen, S.S., Hsu, W.M., Liao, Y.F., Wu, P.Y., Hsia, H.Y., Chang, C.C., and Lee, H. (2014). Calreticulin activates beta1 7.integrin via fucosylation by fucosyltransferase 1 in J82 human bladder cancer cells. The Biochemical journal 460, 69-78. Weng, W.C., Lin, K.H., Wu, P.Y., Lu, Y.C., Weng, Y.C., Wang, B.J., Liao, Y.F., Hsu, W.M., Lee, W.T., and Lee, H. (2014). Calreticulin Regulates VEGF-A in Neuroblastoma Cells. Molecular neurobiology.
  • 研究員 陳倩瑜
    1. Chen, C.Y., Chien, T.Y., Lin, C.K., Lin, C.W., Weng, Y.Z., and Chang, D.T. (2012). Predicting target DNA sequences of DNA-binding proteins based on unbound structures. PloS one 7, e30446.
  • 研究員 許輔
    1. Hsu, H.Y., Kuan, Y.C., Lin, T.Y., Tsao, S.M., Hsu, J., Ma, L.J., and Sheu, F. (2013). Reishi Protein LZ-8 Induces FOXP3(+) Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evidence-based complementary and alternative medicine : eCAM 2013, 513542.
    2. Hung, C.L., Chang, A.J., Kuo, X.K., and Sheu, F. (2014). Molecular cloning and function characterization of a new macrophage-activating protein from Tremella fuciformis. Journal of agricultural and food chemistry 62, 1526-1535.
    3. Kuan, Y.C., Lee, W.T., Hung, C.L., Yang, C., and Sheu, F. (2012a). Investigating the function of a novel protein from Anoectochilus formosanus which induced macrophage differentiation through TLR4-mediated NF-kappaB activation. International immunopharmacology 14, 114-120.
    4. Kuan, Y.C., Sheu, F., Lee, G.C., Tsai, M.W., Hung, C.L., and Nan, F.H. (2012b). Administration of recombinant Reishi immunomodulatory protein (rLZ-8) diet enhances innate immune responses and elicits protection against nervous necrosis virus in grouper Epinephelus coioides. Fish & shellfish immunology 32, 986-993.
    5. Lu, Y.T., Kuan, Y.C., Chang, H.H., and Sheu, F. (2014). Molecular cloning of a Poria cocos protein that activates Th1 immune response and allays Th2 cytokine and IgE production in a murine atopic dermatitis model. Journal of agricultural and food chemistry 62, 2861-2871.
    6. Tsao, Y.W., Kuan, Y.C., Wang, J.L., and Sheu, F. (2013). Characterization of a novel maitake (Grifola frondosa) protein that activates natural killer and dendritic cells and enhances antitumor immunity in mice. Journal of agricultural and food chemistry 61, 9828-9838.
  • 研究員 詹迺立
    1. Wu, C.C., Li, Y.C., Wang, Y.R., Li, T.K., and Chan, N.L. (2013). On the structural basis and design guidelines for type II topoisomerase-targeting anticancer drugs. Nucleic acids research 41, 10630-10640.
  • 研究員 丁詩同
    1. Chou, S.M., Lai, W.J., Hong, T.W., Lai, J.Y., Tsai, S.H., Chen, Y.H., Yu, S.H., Kao, C.H., Chu, R., Ding, S.T., Li, T.K., and Shen, T.L. (2014). Synergistic property of cordycepin in cultivated Cordyceps militaris-mediated apoptosis in human leukemia cells. Phytomedicine : international journal of phytotherapy and phytopharmacology 21, 1516-1524.
    2. Tai, C.C., and Ding, S.T. (2010). N-3 polyunsaturated fatty acids regulate lipid metabolism through several inflammation mediators: mechanisms and implications for obesity prevention. The Journal of nutritional biochemistry 21, 357-363.
    3. Yen, C.F., Lin, E.C., Wang, Y.H., Wang, P.H., Lin, H.W., Hsu, J.C., Wu, L.S., Jiang, Y.N., and Ding, S.T. (2009). Abundantly expressed hepatic genes and their differential expression in liver of prelaying and laying geese. Poultry science 88, 1955-1962.
    4. Yu-Jen Chen, W.-H.K., Jui-Ting Yang, Chih-Chien Chen and Shih-Torng Ding. (2013). Isolation of adipose-derived stem cells from human breast subcutaneous adipose tissues and their differentiation into beige adipose tissue-like adipocytes. The FASEB Journal 27.
  • 研究員 陳明汝
    1. Chen, Y.P., and Chen, M.J. (2013). Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on germ-free mice. PloS one 8, e78789.
    2. Chen, Y.P., Hsiao, P.J., Hong, W.S., Dai, T.Y., and Chen, M.J. (2012). Lactobacillus kefiranofaciens M1 isolated from milk kefir grains ameliorates experimental colitis in vitro and in vivo. Journal of dairy science 95, 63-74.
    3. Chen, Y.P., Lee, T.Y., Hong, W.S., Hsieh, H.H., and Chen, M.J. (2013). Effects of Lactobacillus kefiranofaciens M1 isolated from kefir grains on enterohemorrhagic Escherichia coli infection using mouse and intestinal cell models. Journal of dairy science 96, 7467-7477.
    4. Dai, T.Y., Wang, C.H., Chen, K.N., Huang, I.N., Hong, W.S., Wang, S.Y., Chen, Y.P., Kuo, C.Y., and Chen, M.J. (2011). The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on Staphylococcus aureus-Infected Mice. Evidence-based complementary and alternative medicine : eCAM 2011, 534069.
    5. Hsieh, H.H., Wang, S.Y., Chen, T.L., Huang, Y.L., and Chen, M.J. (2012). Effects of cow's and goat's milk as fermentation media on the microbial ecology of sugary kefir grains. International journal of food microbiology 157, 73-81.
    6. Kuo, C.Y., Wang, T., Dai, T.Y., Wang, C.H., Chen, K.N., Chen, Y.P., and Chen, M.J. (2012). Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on the Prevention of an Allergic Airway Response in Mice. Evidence-based complementary and alternative medicine : eCAM 2012, 481318.
    7. Wang, S.Y., Ho, Y.F., Chen, Y.P., and Chen, M.J. (2015). Effects of a novel encapsulating technique on the temperature tolerance and anti-colitis activity of the probiotic bacterium Lactobacillus kefiranofaciens M1. Food microbiology 46, 494-500.
    8. Wang, S.Y., Chen, H.C., Dai, T.Y., Huang, I.N., Liu, J.R., and Chen, M.J. (2011). Identification of lactic acid bacteria in Taiwanese ropy fermented milk and evaluation of their microbial ecology in bovine and caprine milk. Journal of dairy science 94, 623-635.
    9. Wang, S.Y., Chen, K.N., Lo, Y.M., Chiang, M.L., Chen, H.C., Liu, J.R., and Chen, M.J. (2012). Investigation of microorganisms involved in biosynthesis of the kefir grain. Food microbiology 32, 274-285.
  • 副研究員 范士岡
    1. Min-Yu Chiang, Yao-Wen Hsu, Hsin-Yi Hsieh, San-Yuan Chen and Shih-Kang Fan(2016) Constructing 3D heterogeneous hydrogels from electrically manipulated prepolymer droplets and crosslinked microgels Science Advances Vol.2 No.10 E1600964